作者：邓文清¹, 王滨¹, 王忠¹, 张苏敏¹, 潘义¹, 黄科²

作者单位：1. 中国测试技术研究院，四川 成都 610056;
2. 四川师范大学化学与材料科学学院，四川 成都 610066

关键词：Au/Ag纳米团簇;功能化;分析传感;金属离子;生物分子

摘要：

金属纳米团簇（NCs，尺寸通常小于2 nm）是一类新型的发光纳米材料，由于具有稳定性高、生物相容性好、毒性低等优点成为分析传感领域研究热点。 Au/Ag双金属纳米团簇由于“银效应”使其比传统的AuNCs和AuNCs具有更高的量子产率和更强的稳定性，具有更广阔的应用前景。该文综述近年来Au/Ag双金属纳米团簇的表面功能化及其在分析传感方面的研究进展和分析原理，具体内容包括肽链、蛋白质、DNA对Au/Ag纳米团簇的表面功能化以及功能化的纳米团簇对金属离子、生物小分子和生物酶的分析检测应用。最后总结当前Au/Ag纳米团簇的合成及其在传感分析方面面临的挑战，并对今后的发展进行展望。希望能为Au/Ag纳米团簇在生物传感领域进一步发展提供参考。

Functionalization and sensing application of Au/Ag bimetallic nanoclusters
DENG Wenqing¹, WANG Bin¹, WANG Zhong¹, ZHANG Sumin¹, PAN Yi¹, HUANG Ke²
1. National Institute of Measurement and Testing Technology, Chengdu 610056, China;
2. College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610066, China
Abstract: Metal nanoclusters（NCs，usually smaller than 2 nm in size）, as a new type of luminescent nanomaterials, have become a research hotspot in the field of analytical sensing due to Due to their high stability, good biocompatibility, and low toxicity. Au/Ag bimetallic nanoclusters have higher quantum yield and stronger stability than traditional AuNCs and AuNCs due to the “silver effect”, and have a broader application prospect. In this paper, the surface functionalization of Au/Ag bimetallic nanoclusters in recent years and its research progress and analysis principle in analytical sensing are reviewed. This paper specifically introduced the functionalization of peptide chains, proteins, and DNA for nanoclusters, and its application in the analysis of metal ions, biological small molecules, and biological enzymes. Finally, the current synthesis of Au/Ag nanoclusters and their challenges in sensing detection are summarized, and an expectation for the future development has been made. It is hoped to provide reference for the further development of Au/Ag nanoclusters in the field of biosensing.
Keywords: Au/Ag NCs;functional;analytical sensing;metal ion;biomolecules
2022, 48(9):53-62  收稿日期: 2021-03-24;收到修改稿日期: 2021-05-27
基金项目: 国家标准物质资源共享平台资助项目（APT2002-1）
作者简介: 邓文清（1992-），女，四川广安市人，助理工程师，硕士，主要从事分析检测工作
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