作者：陈鹏飞, 宋航, 李福林, 唐梦雨, 周鲁
作者单位：四川大学化学工程学院制药与生物工程系, 四川 成都 610065
关键词：磁性纳米颗粒;β-环糊精;靶向载体;载药性能
摘要：
以可聚合的-环糊精衍生物丁烯二酸单酯化--环糊精为功能单体，在一定的条件下，与采用含有乙烯基的偶联剂进行表面改性的Pb3O4纳米颗粒，通过自由基共聚法，制备一种带有环糊精基团的磁性纳米颗粒。通过扫描电子显微镜和透射电子显微镜表征其形貌；红外光谱和X-射线衍射表征结构；振动样品磁强计表征其磁性；热重分析仪表征热稳定性。随后对其在不同表面活性剂中的分散稳定性进行测定，并通过细胞毒性试验对含有表面活性剂的分散体系的生物相容性进行研究。在此基础上，以抗癌药物卡莫氟为模型药物考察载体的载药性能。实验结果表明该磁性纳米颗粒有望作为药物载体应用在抗肿瘤药物靶向给药领域。
Preparation and characterization of magnetic nanoparticles based on maleated-β-cyclodextrin
CHEN Pengfei, SONG Hang, LI Fulin, TANG Mengyu, ZHOU Lu
Department of Pharmaceutical Engineering and Biological Engineering, School of Chemical Engineering, Sichuan University, Chengdu 610065, China
Abstract: Maleated-β-cyclodextrin was first synthesized and then its functionalized Pb3O4 magnetic nanoparticles MA-CD-MNPs were prepared via free radical copolymerization of maleated-β-cyclodextrin on the surface of Pb3O4 magnetic nanoparticles(MNPs) modified by 3-methacryl oxypropylt rimethoxy silane which has reactive double carbon bonds. The morphology, structure, magnetic property, and component of MA-CD-MNPs were characterized by SEM, TEM, FT-IR, XRD, VSM and TGA. The colloidal stabilities of MA-CD-MNPs in kinds of surfactant were investigated. Furthermore, the cell cytotoxicity of nanosystem containing the surfactant was assessed by MTT assay. And then, carmofur was selected as model drug to investigate the loading capacity of the MA-CD-MNPs. The MA-CD-MNPs were anticipated to act as a promising candidate of targeted nanocarrier for anti-cancer drugs.
Keywords: magnetic nanoparticles;β-cyclodextrin;targeted nanocarrier;loading capacity
2017, 43(4): 38-43 收稿日期: 2016-11-10;收到修改稿日期: 2016-12-25
基金项目:
作者简介: 陈鹏飞(1989-),男,博士,研究方向为磁性聚合物功能材料。
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