作者：邓文清, 代蕊, 江雪, 罗虹, 黄科, 熊小莉

作者单位：四川师范大学化学与材料科学学院, 四川 成都 610066

关键词：量子点;合成;功能化;生物应用

摘要：

量子点是一种新型荧光纳米材料，具有独特而优良的荧光性质，近年来受到研究者的广泛关注。文章综述蛋白质、抗体、肽类以及DNA等对CdSe量子点（CdSe QDs）的表面功能化作用，以及CdSe QDs在生物传感分析中的重要研究进展。具体介绍CdSe量子点的多种合成方法（包括有机相合成、水相合成等），蛋白质、抗体、肽类、DNA利用共价键或静电作用对CdSe量子点修饰方法，以及其在生物医学标记与成像、生物传感、药物载送以及癌症治疗等领域的相关应用，最后针对现有研究的不足进行展望。希望通过对CdSe量子点全方位总结与概述，在一定程度上帮助科研工作者快速、准确了解其相关性质与研究进展。

Synthesis, functionalization and bio-applications of CdSe quantum dots

DENG Wenqing, DAI Rui, JIANG Xue, LUO Hong, HUANG Ke, XIONG Xiaoli

College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610066, China

Abstract: Quantum dots, a new kind of luminescent nanometer material with unique and excellent fluorescent properties, have drawn much attention of researchers in recent years. In this article, the surface functionalization of proteins, antibodies, peptides and DNA on the CdSe quantum dots(CdSe QDs) and its important research progress in biosensor analysis have been reviewed in details. This article specifically introduced the various synthetic methods of CdSe QDs including organic phase synthesis, aqueous synthesis and so on, the modification of proteins, antibodies, peptides and DNA for CdSe QDs by covalent bond or electrostatic interactions, and its application in biological fields, such as biomedical labeling and imaging, biosensor, drug delivery and cancer treatment. Finally, a summary and expectation for the deficiency of related study of CdSe QDs have been made. It will be helpful for researchers to understand their related properties and research progress quickly and accurately to some extent based on all-around summary and overview for CdSe QDs.

Keywords: quantum dots;synthesis;functional;bio-application

2017, 43(11): 51-58  收稿日期: 2017-03-18;收到修改稿日期: 2017-05-10

基金项目: 国家自然科学基金（21605108）；四川师范大学实验室及设备管理处基金（ZZYQ2016-1）

作者简介: 邓文清(1992-),女,四川广安市人,硕士研究生,专业方向为光谱分析。

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