作者：吕昊1,2, 张玉兰1, 孙羽婕1, 欧阳玉平3, 孙嗣旸1, 胡雅琴1
作者单位：1. 中国测试技术研究院, 四川 成都 610021;
2. 四川大学分析测试中心, 四川 成都 610061;
3. 吉林四长制药有限公司, 吉林 梅河口 135000
关键词：灯盏花素;元素迁移;ICP-AES;ICP-MS
摘要：
以湿法消解对低硼硅玻璃安瓿瓶包装的灯盏花素葡萄糖注射液进行消解,建立ICP-AES及ICP-MS测定其中Al、Ca、K、Na等14种元素的方法,并从检出限、定量限、重复性等方面进行验证。结果表明:该方法检出限为0.009 ng/mL(Ni)～0.03 g/mL(Al);定量限为0.03 ng/mL(Ni)～0.09 g/mL(Al)。平均加标回收率介于95.6%～101.4%之间。
Study on element migration in ampoules of scutellarin glucose injection
LÜ Hao1,2, ZHANG Yulan1, SUN Yujie1, OUYANG Yuping3, SUN Siyang1, HU Yaqin1
1. National Institute of Measurement and Testing Technology, Chengdu 610021, China;
2. Analytical and Testing Center of Sichuan University, Chengdu 610061, China;
3. Jilin Sichang Pharmaceutical Limited Company, Meihekou 135000, China
Abstract: A method with ICP-AES and ICP-MS has been established to determine the Al, Ca, K and Na and ten other elements in scutellarin glucose injection contained in low-borosilicate glass ampoules by means of wet digestion. The method has been verified in respect to detection limit, quantitative limit, repeatability, etc. The detection limit is 0.009 ng/mL(Ni)-0.03 μg/mL(Al), the quantitative limit is 0.03 ng/mL(Ni)-0.09 μg/mL(Al), and the average recovery is 95.6%-101.4%.
Keywords: scutellarin;element migrate;ICP-AES;ICP-MS
2015, 41(12): 36-40 收稿日期: 2015-06-26;收到修改稿日期: 2015-08-20
基金项目:
作者简介: 吕昊(1978-),男,四川成都市人,研究员,博士,主要从事元素分析研究。
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