作者：康晓斌1, 黄勇2, 李朴3
作者单位：1. 青海红十字医院, 青海 西宁 810000;
2. 中国测试技术研究院, 四川 成都 610021;
3. 遵义市质量检验检测院, 贵州 遵义 563000
关键词：骨密度体模;DXA骨密度仪;羟磷酸钙;骨矿含量;骨密度
摘要：
研究比较国产QC-2型骨密度仪试验体模（以下称QC-2或QC-2体模）和美国仿真体模（bona fide phantom，以下称BFP或BFP体模），在双能X射线全身骨密度仪（以下称DXA或DXA仪）试验中测试结果的一致性。用美国Hologic公司的DXA分别对这两种体模的仿真骨骨密度进行测试的方法，对仪器测量结果进行比较研究分析。Hologic仪器对QC-2型体模和BFP体模分别进行测量时，仪器测量的骨密度（以下称BMD）同对应体模的BMD标称值相比，测量误差分别为：对QC-2体模在-10.0%～4.0%范围，对BFP体模在-6.7%～1.7%范围；仪器测试值与两个体模各自的标称值之间，都有高度的线性相关性，r0.99。回归分析：用回归方程进行校正后，测试值（BMD）与QC-2体模和BFP体模的各自的标称值之间的误差分别在-1.0%～1.0%和-1.9%～1.65%范围。表明这两种骨密度体模用于双能X射线全身骨密度仪（DXA）的正确性进行测试，其结果有很好的一致性。
Comparative study on test phantom of two kinds of whole-body bone mineral density instrument
KANG Xiaobin1, HUANG Yong2, LI Pu3
1. Red Cross Hospital in Qinghai, Xining 810000, China;
2. National Institute of Measurement and Testing Technology, Chengdu 610021, China;
3. Zunyi Quality Inspection Testing Institute, Zunyi 563000, China
Abstract: The consistency of test results was tested during dual-energy X-ray absorptiometry (hereinafter referred to as the DXA instrument) test based on the research and comparison between domestic QC-2 body bone mineral density instrument test phantom(hereinafter referred to as the QC-2 or QC-2 phantom) and the US emulational phantom(Bona Fide Phantom, hereinafter referred to as the BFP or BFP phantom). Instrument measurement results were compared, researched and analyzed by respectively measuring the BMD of bio-mimic bone of two types of phantom via the DXA of US Hologic Company. The measuring error of BMD measured by instruments (compared with the nominal BMD value of relevant phantom) when respectively measuring QC-2 phantom and BFP phantom via Hologic instruments:QC-2 phantom is within the range of-10.0%-4.0% and BFP phantom is within the range of-6.7%-1.7%. Besides, there is highly linear correlation r>0.99 between instrument measuring value and nominal value of two phantoms. Regression analysis:after correction via regression equation, the error between tested value(BMD) and nominal values of QC-2 phantom and BEP phantom is respectively within-1.0%-1.0% and-1.9%-1.65%. It shows that the correctness test has an excellent consistency by using the two kinds of BMD phantom for DXA.
Keywords: bone mineral density phantom;DXA bone mineral density instrument;hydroxy calcium phosphate;bone mineral content;bone mineral density
2016, 42(12): 140-144 收稿日期: 2016-07-25;收到修改稿日期: 2016-09-13
基金项目:
作者简介: 康晓斌(1960-),男,青海西宁市人,高级工程师,主要从事医院的设备管理及检定检测。
参考文献
[1] 鄢铃,张园月,魏川,等. DXA骨密度标准体模的研究[J].中国测试,2009,35(1):28-30.
[2] PEARSON D, CAWTE S A, GREEN D J. A comparison of phantoms for cross-calibration of lumbar spine DXA[J]. Osteoporosis Int,2002(13):948-954.
[3] JACKSON S A, MILLER C G J. Choice of cross-calibration phantom for DXA of the lumbar spine and total hip[J]. Bone Min Res,2003,18(2):314.
[4] 胡静,林滔,鄢铃. 两种DXA骨密度体模的比较研究[J].中国测试,2014,40(3):35-38.
[5] KALENDER W A. A phantom for standarization and quality control in spinal bone mineral measurements by QCTand DXA:Design considerations And specifications[J]. Medical Physics,1992,19(3):583-586.
[6] 包安德,马海波,秦林林,等. 不同双能X射线骨密度仪的欧洲腰椎体模测定结果的比较研究[J].核电子学与探测技术,1999,19(5):352-354.
[7] 杨定焯,尚家芸,宋文忠,等. DXA测量用校正脊椎体模的研制及临床测试[J]. 中国医学科学院学报,2003,25(3):264-266.
[8] 方积乾,王显红. 骨密度测量的统计质量控制[J]. 中国骨质疏松杂志,2003,9(3):273-275.
[9] 杨定焯,尚家芸. 骨密度测量中质量控制[M]. 1版. 骨矿与临床. 北京:中国科学技术出版社,2006:303-308.
[10] 杨定焯,安珍,李金祥,等. DXA骨密度测量中精确度和准确度的意义[J]. 中国骨质酥松杂志,1998,4(3),5-7.
[11] 朱晓颖,朱汉民,张雪梅. Hologic和Norland骨密度仪的精密度比较和数据换算[J]. 中国骨质疏松杂志,2005,11(2):189-192.
[12] 郭郡浩,杨路昕,赵智明,等. Prodigy型骨密度仪测量骨密度的变异系数研究[J]. 徐州医学院学报,2009,29(6):399-400.
[13] 郭郡浩,施慧鹏,赵燕玲. DXA测量骨密度的精确度评估[J]. 徐州医学院学报,2010,30(1):40-44.
[14] GRAMPP S. 骨质疏松症影像学[M]. 2版. 程晓光,译. 北京:人民军医出版社,2011:128-128.
