作者：陈秋竹¹, 吴思娴^2,3, 余洋⁴, 秦朗⁵, 许文明^2,4, 应斌武⁶, 孙群⁴

作者单位：1. 四川大学华西第二医院 出生缺陷与相关妇儿疾病教育部重点实验室，四川 成都 610041;
2. 四川大学 生物治疗国家重点实验室，四川 成都 610041;
3. 四川大学华西药学院，四川 成都 610041;
4. 四川大学华西第二医院妇产科生殖医学中心，四川 成都 610041;
5. 四川大学生命科学学院 生物资源与生态环境教育部重点实验室，四川 成都 610041;
6. 四川大学华西医院实验医学科，四川 成都 610041

关键词：COVID-19;2019-nCoV;SARS;MERS;诊断标准;临床特征

摘要：

2019年末武汉爆发新型冠状病毒（2019-nCoV）引起的新型肺炎，由WHO命名为COVID-19。由于2019-nCoV是新发病毒，因此可用的诊断工具非常少，已表明2019-nCoV比SARS-CoV和MERS-CoV的传染性更强，并且COVID-19在短时间内发病数增加迅速，蔓延全球。因此，该文依照文献调研及引文分析方式，对COVID-19的诊断方法进行介绍，同时将其与SARS、MERS患者的临床特征及诊断技术对比，对该疾病的精准临床诊断提供参考，有利于新型冠状病毒肺炎的早期控制并及时有效治疗。

Laboratory diagnostic technology of novel coronavirus pneumonia COVID-19 and its differentiation from the related diseases
CHEN Qiuzhu¹, WU Sixian^2,3, YU Yang⁴, QIN Lang⁵, XU Wenming^2,4, YING Binwu⁶, SUN Qun⁴
1. Gynaecologic and Paediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China;
2. State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China;
3. The College of Pharmacy, Sichuan University, Chengdu 610041, China;
4. Center of Reproductive Medicine, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China;
5. Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610041, China;
6. Department of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu 610041, China
Abstract: From the late 2019, a new type of pneumonia, named as COVID-19 by WHO, caused by a novel coro-navirus (2019-nCoV) occurs in Wuhan, Hubei, China. Since 2019-nCoV is a novel virus, there are few diagnostic tools available. It is shown that 2019-nCoV is more infectious than SARS-CoV and MERS-CoV, and the number of its onset has increased rapidly in a short period of time over the world. Therefore, by performing literature study and citation analysis, this review introduces the diagnosis methods for COVID-19 and compares the clinical features and diagnostic techniques of COVID-19 with those of SARS and MERS, so as to offer suggestion to the accurate clinical diagnosis of this disease, which is beneficial to the early control and the timely effective treatment of COVID-19.
Keywords: COVID-19;2019 - nCoV;SARS;MERS;diagnostic criteria;clinical features
2020, 46(3):64-72  收稿日期: 2020-03-01;收到修改稿日期: 2020-03-20
基金项目: 成都市重点研发支撑计划（2020-YF05-00306-SN）
作者简介: 陈秋竹(1999-),女,贵州安顺市人,专业方向为药学
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