作者：王驰¹, 陈斐璐¹, 杨风辉², 任丹阳¹, 孙建美¹

作者单位：1. 上海大学精密机械工程系，上海 200444;
2. 海军军医大学第一附属医院医学工程科，上海 200433

关键词：扫频OCT;超小GRIN光纤探头;生物组织成像;内窥检测

摘要：

研究基于超小GRIN光纤探头的扫频光学相干层析成像（SS-OCT）系统及其性能测试方法。首先，在论述超小GRIN光纤探头及其在OCT信号臂应用方法的基础上，研制超小GRIN光纤探头样品并用于SS-OCT系统的搭建；其次，利用国际分辨率板A3和标准盖玻片进行SS-OCT系统的性能测试，得到所搭建的SS-OCT的横、纵向分辨率分别为33.6 μm、14.8 μm；最后，利用猪支气管和猪心等不同生物组织作为待测对象进行成像研究，获得相应的层析图。结果表明：所研究的基于超小GRIN光纤探头的SS-OCT系统有微米级的高分辨率，可用于生物组织内窥OCT成像检测方法的进一步研究。

Research on SS-OCT imaging system based on ultra-small GRIN fiber probe
WANG Chi¹, CHEN Feilu¹, YANG Fenghui², REN Danyang¹, SUN Jianmei¹
1. Dept. of Precision Mechanical Engineering, Shanghai University, Shanghai 200444, China;
2. Medical Engineering Department, the First Hospital Affiliated to Naval Military Medical University, Shanghai 200433, China
Abstract: Based on the ultra-small gradient-index (GRIN) fiber probe, a swept source optical coherence tomography (SS-OCT) system and its performance testing method are studied. Firstly, by describing the discussion of the ultra-small GRIN fiber probe and its application method in the OCT signal arm, the ultra-small GRIN fiber probe sample was developed and used for the construction of the SS-OCT system. Secondly, the performance test of the SS-OCT system was performed by using the international resolution plate A3 and standard coverslips, and the transverse and longitudinal resolutions of the constructed SS-OCT were obtained as 33.6 μm and 14.8 μm respectively. Finally, experiments were performed by using different biological tissues such as porcine bronchus and porcine heart as the imaging objects to be measured, and their corresponding chromatograms were obtained. The results showed that, the proposed SS-OCT system based on the ultra-small GRIN fiber probe has a micron-level high resolution and can be used for further research of biological tissue endoscopic OCT imaging detection methods.
Keywords: SS-OCT;ultra-small GRIN fiber probe;biological tissue imaging;endoscopic inspection
2022, 48(12):1-6  收稿日期: 2022-02-27;收到修改稿日期: 2022-04-12
基金项目: 国家自然科学基金（62175144）；上海市科技创新行动计划（20142200100）
作者简介: 王驰(1982-),男,河南周口市人,教授,博士(后),主要从事精密测试仪器方面的研究
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